Understanding how this medication affects metabolism, what happens after discontinuation, and strategies to maintain metabolic health can help patients make informed treatment decisions
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Discuss all risks and benefits with your doctor, especially if you are pregnant, breastfeeding, or have a history of heart, kidney, or electrolyte disorders
Metformin is more affordable but less effective for weight loss
In clinical trials: Semaglutide: Approximately 7% discontinued due to adverse events Tirzepatide: Approximately 4-7% discontinued due to adverse events (dose dependent) Retatrutide: Approximately 6-10% discontinued due to adverse events (dose dependent) These rates are relatively close, suggesting that despite the differences in mechanism and side effect profiles, all three medications are tolerable for the vast majority of people who start them
Before trying any new treatment, I always want to know if it's backed by science and regulatory approval