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The processes involved in their development, particularly in association with CKD, can be attributed to hypervolaemia, systemic arterial resistance, elevated blood pressure, large vessel compliance, and activation of pathways related to the parathyroid hormonevitamin Dphosphate axis
Essien, MD, MPH, assistant professor of medicine at the University of Pittsburgh School of Medicine and core investigator in the Center for Health Equity and Research Promotion at the VA Pittsburgh Healthcare System, and colleagues wrote that as novel, effective and often costly drugs are approved for use and incorporated into clinical practice guidelines, a disturbing pattern of care is evident: Uptake and diffusion of recommended, evidence-based therapies increase over time, whereas individuals from underrepresented racial and ethnic groups receive these medications less often
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