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PKA causes membrane depolarization and eventually Ca2+ release via the Inositol Triphosphate pathway (IP3)

GLP-1 receptor agonists stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning they only promote insulin release when blood glucose levels are elevated

10.1016/j.jacc.2021.12.011 31 HermansenK.BkdalT

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This approach is key to understanding the specific effects of the retatrutide dosage schedule after high dose of tirzepatide