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GLP-1 Agonists and Athletic Performance: What We Know (and Don't Know) Research specific to endurance athletes and GLP-1 RAs is extremely limited

Desensitization and Diminished Effects IGF-1 receptor downregulation can occur with chronic use, diminishing results over time and increasing the need for cycling or periodization

September 2023 FDA added ileus warnings

[1] [2] Peptic ulcers are localised areas of erosion in the lining of the stomach or duodenum, typically caused by infection with Helicobacter pylori bacteria or the use of non-steroidal anti-inflammatory drugs (NSAIDs)

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Inhibition of ASK1 has therefore been proposed as a target for the treatment of NASH