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However, the cellular stress of the upstream events, i.e., reactive metabolite formation, GSH depletion, and protein adducts formation, is still present and this stress may trigger apoptosis in a limited number of cells (Figure 1)
Expert Opin Pharmacother 2011;12:143951.ArticlePubMed 98
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This leads to its marked depletion with a concomitant increase of activity in the PPP as the primary mechanism to generate more reducing equivalents of NADPH
A number of tissues contain significant concentrations of ALC but these decrease as we age and there is evidence that dietary supplementation can address these shortfalls
