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However, the ACA left in place the existing prohibition on Medicare negotiating drug prices a policy originally set by the 2003 Medicare Modernization Act in part to maintain support from pharmaceutical industry stakeholders

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That narrow majority put the committee on the opposite side of FDA staff, whose written review recommended against inclusion

For the millions of people with MASLD who currently have no approved pharmacological treatment, retatrutide represents potentially transformative therapy

Approval would greatly expand access and possibly lower cost through insurance coverage

For drug development, the GLP-1 receptor agonist structure should also be considered, since ligand orientation, peptide modifications, and half-life-extending features directly influence pharmacokinetics and receptor interactions