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Phase 1a: First-in-Human Single Ascending Dose Study (NCT02951806) Study Title: "Safety, Tolerability, and Pharmacokinetics of Single Doses of Cagrilintide in Healthy Subjects" Status: Completed Phase: Phase 1a Enrollment: 48 healthy volunteers Study Period: 2016-2017 Location: Single center (Denmark) Design: Randomized, double-blind, placebo-controlled, single ascending dose Dose Range: 0.03-10 mg SC Primary Endpoints: Safety, tolerability, PK parameters Population: Healthy male subjects, BMI 20-28 Key Results: Pharmacokinetics: Terminal half-life 5-7 days across dose range

Proc Natl Acad Sci USA 97 , 46094614 (2000)

It also has insulin-sensitising effects, which is why it was first tested in PCOS rather than as a generic egg supplement

Allergic reactions , whilst rare, can occur and range from mild skin reactions to severe anaphylaxis

American Journal of Medicine

GHK-Cu is commonly researched for its potential interaction with: Collagen-related and extracellular-matrix pathways Skin-integrity and elasticity-related mechanisms Dermal-maintenance and regenerative signaling Hair- and scalp-related research pathways Cellular-repair and physiological-resilience mechanisms Healthy-aging and skin-quality investigations Because of its broad regenerative and collagen-related research profile, GHK-Cu is frequently investigated in skin-integrity, tissue-maintenance, recovery-focused, and regenerative research models