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-22.5% Avg body weight loss at highest dose (SURMOUNT-1) 96% Lost at least 5% body weight 72 weeks Trial duration Context: Clinical trial participants also received lifestyle intervention (diet and exercise counseling)

Food and Drug Administration to establish their safety, effectiveness, quality, or manufacturing consistency

As of August 2024, three doses of Wegovy remain in limited availability: 0.25 mg/0.5 mL 0.5 mg/0.5 mL 1 mg/0.5 mL The FDA database lists the estimated shortage duration for these doses as "TBD" (To Be Determined)

The most realistic near-term path to expanded coverage is Scenario 2 (sleep apnea indication)

Current Obesity Reports Journal

The medium was replaced, and after 8 h the cell supernatant was collected and co-incubated with RAW264.7 cells for 4 h