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This includes determining the appropriate dosage, administration method, and monitoring protocols

Challenges include gastrointestinal side effects, nutritional deficiencies due to calorie reduction, muscle and bone loss, low long-term adherence with subsequent weight regain, and high costs, resulting in low cost-effectiveness

Trends in the incidence of diabetes mellitus: results from the global burden of disease study 2017 and implications for diabetes mellitus prevention

(2015) 10:e0126027

M., Gu, X

GPX3 can suppress the expression of HIF-1 by regulating ROS, affecting tumor cell energy metabolism, and inhibiting the growth of melanoma cells (51)