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GLP-1RAs enhance insulin secretion and inhibit glucagon release by the pancreas, resulting in glucose-dependent reductions in plasma glucose

We demonstrated that GLP-1 enhances physical endurance by inducing skeletal muscle remodeling, which may be mediated by GLP-1R/AMPK signaling

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Abbreviations ( Cyp11a1 ): Cytochrome P450 family 11 subfamily a polypeptide 1 (ELISA): Enzyme Linked Immunosorbent Assay (FSH): Follicle-Stimulating Hormone (GnRH): Gonadotropin-Releasing Hormone (LC): L-carnitine, (LH): Luteinizing Hormone (MDA): Malondialdehyde (MSG): Monosodium Glutamate (ROS): Reactive Oxygen Species ( Star ): Steroidogenic Acute Regulatory protein (TAC): Total Anti-oxidant Capacity ( Hsd17b3 ): 17-Hydroxysteroid dehydrogenase-3 References Vander Borght M, Wyns C

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The fact that the findings were similar across CFS and hypothyroidism points to the possibility that low peripheral serotonin may be a common theme across some disorders that include fatigue