In muscle tissue, IGF-1 LR3 is instrumental in increasing the DNA and RNA synthesis, which are crucial for protein synthesis and muscle cell proliferation, leading to hyperplasia (increase in the number of muscle cells) and hypertrophy (enlargement of existing muscle cells)
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These data confirm the role of IGF-I/IGF-IR signaling in modulating vital functions of chondrocytes and the overall pace of endochondral bone formation in embryos
Li HX, Fu XJ, Yang K, Chen D, Tang H, Zhao Q (2016) The clock gene PER1 suppresses expression of tumor-related genes in human oral squamous cell carcinoma
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Higher serum IGF-1 levels were associated with increased risk of cancer death in older community-dwelling men [28]
