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Degraded medication may be ineffective or produce harmful byproducts

& Olson, E.N

For example, opioids decrease pulmonary perfusion via hypoxia-induced pulmonary vasoconstriction 143 , and by direct pulmonary vasoconstriction 144,145 by mechanisms including centrally-mediated activation of sympathetic nerve activity to the lungs 146 , and induction of histamine release in the lungs 144,147

Some researchers also explore topical application in relevant study contexts

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It also helps to prevent the activation of tyrosinase (the enzyme that helps produce more melanin) by reducing free radicals that can activate it and cause an increase in melanin production