Furthermore, GLP-1r / mice had an enhanced level of urinary DPD, which indicated increased bone resorption
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In macrophages, the activation of mGluR5 elevates the level of the nuclear receptor peroxisome proliferator-activated receptor (PPAR) g and promotes a shift from M1 to M2 phenotype, leading to reduced IFN- production [180]
Although sex difference is an important factor in the actions of GLP-1 and its analogs [59], the present study provides no information about this issue