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Additionally, exendin-4 treatment increases c-fos expression in in GLP-1R+ Paneth cells (Figure 1), which is abolished when exendin-(939) is administered prior to exendin-4 treatment (Kedees et al., 2013)

This ensures the full dose is delivered properly into the subcutaneous tissue

A dose-dependent increase in heart rate was also observed

Archives Med Sci

And as we're seeing the influence of these big trials, this is why many cardiology guidelines are now considering GLP ones in high risk patients