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ISRN Biochem 2013:118

A multinational trial of prasugrel for sickle cell vaso-occlusive events

Finally, another report proposed the synthesis of PLGA nanocarriers decorated with PEG and glutathione (GSH), for the intracellular delivery of curcumin: the double functionalization resulted in an increased NP uptake by neuronal cells and, in particular, the GSH conjugation modified the NP internalization pathway, avoiding the lysosomal degradation and increasing the therapeutic fate for potential application in the treatment of AD (Paka and Ramassamy, 2017)

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Proposed axes such as lung-heart ferroptotic coupling are intriguing but currently rest largely on correlative in vivo imaging, inflammatory signaling, and systemic oxidative stress markers rather than direct causal relay experiments