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For mKate reporter construction, the mKate2 gene was amplified from pRN10 (Addgene, plasmid 84454) 69 using a specific primer pair (Supplementary Table 3) and Q5 High-Fidelity DNA Polymerase (New England Biolabs)

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Animal research has demonstrated that DSIP can reduce CRF-induced corticosterone release, suggesting it may help normalize the stress hormone cascade

Moreover, FOXO4-DRI was used to selectively induce apoptosis of senescent fibroblasts in both keloid fibroblast and organ culture senescent models, showing potential as a treatment that targets the senescence and apoptosis resistance observed in keloid fibroblasts

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Predicted binding of certain antifilarial compounds with glutathione-S-transferase of research-subject Filariids