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This means that while your body can usually produce enough of it on its own, there are timessuch as during periods of high physical stress, intense exercise, or recoverywhen your bodys demand for it may exceed its ability to produce it

Walker RF et al

Given this background, a comprehensive assessment of liver functional reserve, quality-of-life impairment, sleep disturbances, fall risk, and driving habits is essential for both determining treatment initiation and evaluating therapeutic response

Gijsbers et al

It can also cause side effects like nausea, vomiting, diarrhea, and constipation, so it should only be used under medical supervision.

Acute kidney injury has also been linked to semaglutide use, though the associated risk is not fully understood