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A moderate dosage titration method is advised to mitigate adverse effects when commencing medication (Bettge et al
Examples of Drugs with Boxed Warnings Some commonly used medications that carry a Boxed Warning include: Accutane (isotretinoin): severe birth defects during pregnancy Methotrexate: liver toxicity and organ damage Ciprofloxacin: increased risk of tendon rupture Opioids (such as oxycodone, fentanyl): high risk of addiction and overdose Antidepressants (SSRIs, SNRIs): increased risk of suicidal thoughts in young adults Atypical antipsychotics (such as aripiprazole, olanzapine): increased risk of death and cerebrovascular events (such as a stroke) in dementia
Important note for oral semaglutide (Rybelsus): According to the SmPC, this medication must be taken on an empty stomach with a small sip of water (up to 120 ml), and patients must wait at least 30 minutes before consuming any food, drink, or other oral medications, including supplements
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Mounjaro may suit better if maximum average weight loss is your primary objective and you do not have established cardiovascular disease
