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The base business delivered double-digit growth, while a 453 Cr shared savings adjustment (SSA) on lenalidomide (post patent expiry, pricing collapsed as competition entered) dragged down reported numbers

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By binding to GLP-1 receptors in the hypothalamus, they reduce appetite and promote satiety, leading to significant weight reduction in clinical trialswith newer agents achieving approximately 15% weight loss in obesity without diabetes (semaglutide) and up to 21% (tirzepatide), with somewhat lower reductions typically seen in patients with type 2 diabetes

When timed appropriately, this combination can provide both effective weight loss and precise body contouring for a more complete transformation

If symptoms of allergic reactions (including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing) occur, patients must stop taking JANUMET and seek medical advice promptly