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Prescribers should be aware that hydroxocobalamin is contraindicated in patients with a known hypersensitivity to cobalt or any other component of the injection solution
The slowed gastric emptying combined with altered gut motility creates unpredictable effects on colonic transit
The substitution wouldn't address the same research question
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There is no published pharmacokinetic study confirming that sublingual SLU-PP-332 produces serum concentrations comparable to IP injection in mice
3 RGN-259 Phase 3 Trial in Neurotrophic Keratopathy Sosne et al., International Journal of Molecular Sciences (2022) This Phase 3 randomized, placebo-controlled, double-masked clinical trial evaluated topical 0.1% RGN-259 (full-length recombinant T4 ophthalmic solution) in patients with neurotrophic keratopathy
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