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Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling

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Lyophilization is a dehydration technique in which compounds are frozen and then exposed to low pressure

Melatonin counteracts this damage by restoring gut microbiota, reducing toxic metabolites, and activating intestinal FXR signaling

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Any deregulation of these two regulatory processes may affect proper oxygen transport to the tissues