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Semaglutide is a synthetic peptide analog that has been specifically engineered in pharmaceutical laboratories to resist degradation and provide prolonged activity compared to native GLP-1

1 1 2 Weight loss outcomes by engagement quartile *Based on a January 2026 analysis of 14,210 Noom GLP-1 Rx program members who joined between December 2024 and February 2025 and logged weight during a measurement week (4, 8, 16, 40 weeks) Total months persisted by engagement quartile *Based on a January 2026 analysis of 30,239 Noom GLP-1 Rx program members who joined between December 2024 and February 2025 Frequently Asked Questions Weight Loss and Engagement: January 2026 analysis of 14,203 Noom GLP-1 Rx Program members who started a GLP-1Rx plan between December 2024 and February 2025 and logged weight during a measurement week (4, 8, 16, 40 weeks)

Dilated cardiomyopathy (DCM) is the most common, marked by ventricular enlargement and systolic dysfunction, often presenting with dyspnea

10.1016/S0140-6736(03)12489-0 35 HatiS.PatelM.MishraB

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Each has a different chemical action and a different side effect profile