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Clinical evidence shows that combining growth hormone secretagogues with GLP-1 agonists can amplify fat oxidation and preserve lean mass during weight loss, but only when injection timing is staggered by at least 46 hours and both medications are titrated separately
Nat Rev Cardiol 9:147157
(A) GLP-1 can induce fibronectin type III domain-containing protein 5 (FNDC5) expression in pancreatic -cells through the interaction of its downstream transcription factor cAMP-response element binding protein (CREB) with binding elements in the FNDC5 promoter, thereby promoting the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT)
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