Strikingly, we uncovered the AKT1-PRMT7-GLUD1 axis as a critical controller of tumor growth, providing a potential target and strategy for clinical treatment of gastric cancer
Consuming leafy greens in their natural state is important
10.1186/s13287-020-01691-x Stem Cell Res
10.3945/jn.109.118216 129 MatooriS.VevesA.MooneyD
The percentage distribution of copper in individual organs and tissues of the human body is estimated as follows: Examples of endogenous processes in which copper plays a role: Under normal circumstances, the amount of copper is highly regulated, as non-protein-bound copper reacts toxically in the body and leads to severe organ damage at high concentrations
These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time
