Nrf2 translocation was assessed by quantification of the mean GFP intensity in the nucleus over time
employed a HFD-induced NAFLD mouse model with hepatocyte-specific ablation of the retinoic acid receptor-related orphan receptor (ROR) (ROR-LKO) to demonstrate that liraglutide alleviated hepatic steatosis via ROR-dependent autophagy activation, thus highlighting another mechanism of autophagy activation by GLP-1RAs [28]
Gastric Pentadecapeptide Body Protection Compound BPC 157 and Its Role in Accelerating Musculoskeletal Soft Tissue Healing Cell and Tissue Research Comprehensive review concluding that all BPC-157 studies demonstrate consistently positive and prompt healing effects for various traumatic and systemic soft tissue injuries including tendons, ligaments, and skeletal muscle
This year, as the dust of the years-long GLP-1 boom started to settle (albeit gradually), an important narrative around obesity came into view: Health is not just about personal choices, but also a complex mix of biology and genetics
L.LaversanneM.SoerjomataramI.JemalA.et al (2021)
Gastrointestinal adverse events were predominantly limited to initial dosing, while dose escalation resulted in lower discontinuation rates owing to these adverse events than among patients who remained on the starting dose