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Managing Digestive Side Effects on GLP-1 Treatment Most gastrointestinal side effects associated with GLP-1 therapy are mild to moderate and tend to improve over time as the body adjusts to treatment

Of those who received Wegovy, 73% lost at least 5% of their starting body weight by the end of the study

If side effects persist, pause the routine and consult your healthcare provider

Gastrointestinal Tract Most GLP-1 is produced in the gastrointestinal (GI) tract and GLP-1R expression has classically been ascribed to myenteric plexus neurons throughout the gut (87)

People who stopped the medication regained weight and saw metabolic markers return toward baseline, which suggests that GLP-1 therapy provides ongoing benefit rather than a one-time reset

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