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Resistance Fold was calculated by dividing the IC 50 value of a substrate drug into drug-resistant KB/CV60 cells in the presence or absence of an inhibitor (sertraline, fluoxetine, citalopram, or ONO-1078) by the IC 50 value of parental KB-3-1 cells without an inhibitor
For context, tirzepatide (marketed as Mounjaro for diabetes, and Zepbound for weight loss/obesity) and semaglutide (Wegovy/Ozempic, etc.) are FDA-approved today and represent the current standard of care for many patients seeking medically guided weight loss
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The post-payment medical history intake was not walked
This study reported one pulmonary aspiration case in a patient under deep sedation despite 12.4 h of fasting (Silveira et al
Screening for eating disorders is also key
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