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They are often down-titrated or discontinued when patients experience hyperkalemia.[38] Observational studies, systematic reviews, and RCTs have demonstrated that discontinuing RAASis is associated with a higher risk of all-cause mortality and increased risk of kidney failure requiring dialysis.[39-41] Similar outcomes have been observed when discontinuing RAASis in patients with restored left ventricular heart failure after an acute myocardial infarction: stopping RAASis was associated with increased risk of all-cause mortality, spontaneous myocardial infarction, and heart failure rehospitalization (11.4% vs 5.4%

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In 17.1% of the cases, oral semaglutide was combined with metformin and SGLT2i, while subcutaneous semaglutide was used in such combination therapy in only 1 case (1.3%) ( p = 0.0008)