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Tirzepatide Plus is a once-weekly GIP (glucose-dependent insulinotropic polypeptide) receptor and GLP-1 (glucagon-like peptide-1) receptor agonist, representing a new class of medicines studied for the treatment of obesity

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The findings that blockade of GLP-1 signalling abolished metformin-induced suppression of hepatic glucose output in rodents [13], and markedly attenuated the effect of metformin in reducing the glycaemic response to a mixed meal in people with type 2 diabetes [14], attest to a major role for GLP-1 in mediating the glucose-lowering effect of metformin

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