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Hyperuricaemia in obese people is mainly caused by impaired renal uric acid clearance, not overproduction (So and Thorens, 2010)
From a purely pharmacological perspective, the two molecules affect partially different receptors, which explains the theoretical interest of the question
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Consistently, the ACSL4 inhibitor rosiglitazone also had kidney protective effects against IRI-induced AKI by reducing the infiltration of immune cells and ferroptotic cell death [48, 151]
After 46 months, labs show improvement but the patient wants to push further on body composition or recovery
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