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It turns out that this little chain of amino acids from heli monster venom turns on the same switches in a mammal's pancreas as GLP-1 does

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PEG modification increased the stability of protein and peptide drugs, increased the solubility, reduced the immunogenicity, prolonged the residence time in blood, reduced the protease degradation, and reduced the frequency of drug use

For a comprehensive overview of how peptides compare across tissue systems, our joint and tendon peptide research guide provides useful context

doi:10.1016/j.ctcp.2017.11.004