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In mice, GDF-15 increases satiety and reduces food intake through actions in the central nervous system [99]

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(1,2) A systematic review found improvements in upper and lower body strength, physical performance, and body composition after 12 weeks of creatine supplementation alongside resistance exercise in healthy older individuals

Watch for these patterns: Your interest in sex dropped noticeably within the first few weeks of starting medication You feel too tired or nauseous for intimacy, especially on dose-escalation days Your desire returned during a break from the medication You notice other hormonal symptoms: hair thinning, mood changes, fatigue, or muscle loss Your partner has noticed a change in your level of interest or responsiveness None of these signs on their own confirm the medication is the cause