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The classic sign is the inability to touch the chin to the chest due to neck rigidity

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19,20 In mice, Klotho deficiency exaggerates isoproterenol-induced pathological cardiac hypertrophy and remodeling, while Klotho overexpression ameliorates isoproterenol-induced cardiac pathologies and improves their long-term survival

Any references, studies or articles sited in this document do not imply that similar results will occur when the same treatment is experienced by another