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Store in a cool, dry place below 25C

Adverse events were classified by severity as mild (easily tolerated, causing minimal discomfort, and not interfering with everyday activities), moderate (causes sufficient discomfort and interferes with normal everyday activities), or severe (prevents normal everyday activities)

Poor fat distribution often translates to increased cholesterol and hypertension

Semaglutide mimics the GLP-1 hormone (glucagon-like peptide-1) and activates GLP-1 receptors found throughout the body, which helps lower appetite, slow digestion, and regulate blood sugar

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Code availability Proteomics data were processed using open-source software: MaxQuant v 1.6 3.4 for DDA experiment ( DIA-NN v1.8 for DIA experiment ( Skyline v.23.1.0.380 ( for SRM and PRM experiments