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In the case of compound 2-bound structure, the N-terminal -helix of ECD penetrated to the TMD core and formed extensive contacts with residues in TM1-3, ECL1, and ECL2, resulting in an ECD-TMD interacting surface area of 1438.4 2 , similar to other small molecule agonists

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(ref) Seiwerth S, Sikiric P, Grabarevic Z, Zoricic I, Hanzevacki M, Ljubanovic D, Coric V, Konjevoda P, Petek M, Rucman R, Turkovic B, Perovic D, Mikus D, Jandrijevic S, Medvidovic M, Tadic T, Romac B, Kos J, Peric J, Kolega Z

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