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On the other hand, also in the extracellular space, the cysteinyl-glycine fraction is split by the enzyme dipeptidase generating cysteine and glycine

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The substitution of carboxamide at the alkyl terminal (KL2, KL4 and KL5) or removal of the nitrile group from the dihydropyridine ring (KL6) moderately reduced their adjuvant activity (Extended Data Fig