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Int J Mol Sci, 21(12):4232
Peripheral administration of the brain penetrant MC3/4R receptor peptide agonist, Melanotan II (MTII), and the highly selective, small-molecule MC4R agonist, Pf-446687, enhanced partner preference formation in the prairie vole, but not in the non-monogamous meadow vole
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What the evidence actually shows The early concern came from spontaneous adverse-event reports and from some pharmacoepidemiology studies that found more pancreatitis diagnoses among GLP-1 users
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