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Valdivielso, P., Ramrez-Bueno, A
5.3 The "Tregs-Microglia-Neuron/NPCs" axis and GLP-1R/cAMP/PKA/IL-10 mediated immunosuppressive and neuroprotective effects of GLP-1RAs in ischemic stroke In summary, in the pathological state of ischemic stroke, T cells preferentially migrated to the lesion boundary, and significantly increased after ischemia, peaking in the following weeks and persisting for several months (71)
Nevertheless, standardization of extracts with respect to key active markers such as 4-hydroxyisoleucine and trigonelline remains a necessary step for optimizing clinical efficacy and ensuring reproducibility across future therapeutic applications (149)
Zemprocitinib also demonstrated a good overall safety and tolerability profile
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