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This is the period where the medication reaches full therapeutic dose (12mg by week 13) and genuine fat oxidation dominates the weight loss pattern

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Other potential risks include pancreatitis, gallbladder disease, diabetic retinopathy complications (with semaglutide), and acute kidney injury if dehydration occurs

It reflects the pharmacokinetic reality of semaglutide, which has a half-life of approximately one week

doi: 10.1016/j.atherosclerosis.2015.03.026 8 LeonardiniADOriaRIncalzaMACaccioppoliCBuccheriVACignarelliAet al

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