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Acknowledgements This work was supported by an NIH Grant CA137230 and a VA Merit Review Grant

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Rotate injection sites to prevent lipodystrophy 9 Store reconstituted solution refrigerated (28C) and use within 28 days Week 12 Initial effects and adaptation period

Compared to twice-daily preclinical dosing with the GLP-1 analogue liraglutide, once-weekly dosing of ZP4982 at almost equimolar doses was superior in terms of body weight loss in an obese rat model (143)