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Additionally, remodeling of the ECM in TDLNs is also thought to occur as part of the pre-metastatic niche formation, but the mechanisms that underlie this process and their molecular players remain to be uncovered ( A single-cell analysis carried out in cells isolated from murine breast cancer models showed changes in immune modulation and metabolism in TDLNs (174)
Mechanisms of MHC-I downregulation and role in immunotherapy response
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