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NNMT (Nicotinamide N-Methyltransferase) is a cytosolic enzyme that catalyses the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide producing 1-methylnicotinamide (1-MNA) and S-adenosyl-homocysteine (SAH) as reaction products
Niacinamide does not cause the dramatic flush of niacin, so titration to mitigate flushing is usually not necessary
Individuals with a known allergy to any of the components, pregnant or breastfeeding women, and those with liver disease or kidney disease should not take this medication
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