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This paradigm shift operates through: (i) dual-function targeting (simultaneous antithrombotic action and regenerative promotion), (ii) spatiotemporal inflammatory reprogramming (controlled macrophage polarization), and (iii) synergistic regenerative factor delivery (orchestrated release of cardioprotective mediators) [62, 94](Fig

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Identifying these conditions early helps guide effective treatment

doi: 10.1034/J.1399-3038.2002.00010.X 236 RosenlundHMagnussonJKullIHkanssonNWolkAPershagenGet al