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In a case study, 5g of creatine per day reduced high homocysteine in a person with the bad MTHFR genotype (677TT) after one month [ R ]

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Systemic administration produced equally impressive results: in cardiac ischemia models, doses ranging from 400 ng to 15 mg per animal reduced infarct size, improved myocardial function, and enhanced survival through activation of integrin-linked kinase and Akt pathways promoting cardiac cell migration and angiogenesis while preventing excessive fibrosis