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In 1986 they first documented a reduced incretin effect in patients with type 2 diabetes ( Diabetologia 29:4652), and then in 1993 they demonstrated that, in patients with poorly controlled type 2 diabetes, a single exogenous infusion of an incretin (GLP-1) increased insulin levels in a glucose-dependent manner and normalised fasting hyperglycaemia ( Diabetologia 36:741744)