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The synergy is multiplicative, not additive

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Metformin enhances mitophagy and mitochondrial function, contributing to improved glucose and lipid metabolism

Diamine Put [NH 2 (CH 2 ) 4 NH 2 ], triamine Spd [NH 2 (CH 2 ) 3 NH(CH 2 ) 4 NH 2 ], tetramine Spm [NH 2 (CH 2 ) 3 NH(CH 2 ) 4 NH(CH 2 ) 3 NH 2 ] are most common PAs in higher plants which exist as soluble conjugated, and insoluble bound forms and differential forms of PAs function differently (Lefevre et al., 2001)

Another study by Pickart et al

doi: 10.1038/s12276-023-00960-y 151 La FataGWeberPMohajeriMH