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They transfer functional cargo to recipient cells, offering advantages including stability, retention capacity, low immunogenicity, and efficient drug delivery, thereby positioning EVs as cell-free therapies for cardiovascular, oncological, and immune disorders [73, 74]
chronic liver disease and hepatitis may present with elevated levels Renal impairment : Reduced clearance can contribute to accumulation, though this is rarely clinically significant Solid tumours : Certain malignancies, particularly hepatocellular carcinoma and metastatic disease, may elevate B12 levels [3] Evidence suggests that unexplained markedly elevated B12 levels without supplementation may sometimes be associated with underlying disease
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L-carnitine has also been studied for its impact on cholesterol
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IGF-1 levels increase significantly but remain within safety thresholds, and no glycemic worsening occurs in type 2 diabetes patients at therapeutic doses
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