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No statistically significant differences were noted between groups regarding serum levels of testosterone, FSH, LH, and prolactin at baseline

and lamotrigine can correct some abnormal markers of bone metabolism (130)

firstly, the accumulation of AGEs engages their receptor RAGE on macrophages, initiating robust pro-inflammatory signaling cascades such as the NF-B pathway, which transcriptionally upregulates key M1 markers (e.g., TNF-, IL-6, iNOS) while suppressing M2-associated genes like Arg1 (Yu et al., 2025)

doi:10.1016/j.cmet.2022.09.018