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This makes injections highly effective for pernicious anaemia and other malabsorption syndromes, including post-gastrectomy states, Crohn's disease affecting the terminal ileum, and certain medications that interfere with B12 uptake

Its plasma concentration decreases with age (200 ng/mL at age 20 vs

The oxidative pathway produces N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive metabolite capable of binding cellular proteins and causing hepatocyte death

Maximum: Up to roughly 4.5 mg weekly in advanced protocols, the dose tied to the greatest weight loss in early trials [4]

Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling

You can take more when you are sick or particularly stressed out