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This is complemented by the incretin effect, insulin-sensitising properties, and promotion of subcutaneous fat accumulation mediated by GIP, as well as the thermogenic and lipolytic actions of GCG (Table 2).54 Its structure resists degradation by DPP-4 and enables binding to albumin, resulting in a half-life of six days, which allows for once-weekly subcutaneous administration

91 It is unclear whether the heart rate increase associated with GLP-1 RAs, which may pose a safety concern in patients with HFrEF, can be mitigated by the concurrent use of -blockers, which are typically prescribed for HFrEF

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Gillespie, C

The extra water retention studies tell us people can pick up 2-3 pounds shows up on the scale, but you shouldnt worry about it

Your doctor may prescribe these medications to control diabetes or support weight management when other approaches have not worked well enough